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Tuesday, November 17, 2020 | History

2 edition of Regulation of Hyaluronan Biosynthesis found in the catalog.

Regulation of Hyaluronan Biosynthesis

Annica Jacobson

Regulation of Hyaluronan Biosynthesis

Expression in Vitro & Importance for Tumor Progression (Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1148)

by Annica Jacobson

  • 268 Want to read
  • 1 Currently reading

Published by Uppsala Universitet .
Written in English

  • Oncology,
  • Medical

  • The Physical Object
    Number of Pages52
    ID Numbers
    Open LibraryOL12854510M
    ISBN 109155453031
    ISBN 109789155453039

    Keywords: Hyaluronan; Hyaluronidase; Oligosaccharides; Glycosaminoglycans; Extracellular matrix Authors: Robert Stern, Akira A. Asari, Kazuki N. SugaharaRobert Stern.

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Regulation of Hyaluronan Biosynthesis by Annica Jacobson Download PDF EPUB FB2

AGING AND REGULATION OF HYALURONAN BIOSYNTHESIS. COMPARATIVE STUDIES ON HUMAN SKIN FIBROBLASTS AND CORNEAL KERA TOCYTES. Robert L.*, Fodil I., Isnard N., Dupuy F., Robert A.M., Renard G. Laboratoire de Recherche en Ophtalmologie, Esc B3 6eme etage, Hotel Dieu, 1 place du Parvis Notre-Dame.

Paris, by: 1. Naoki Itano, Koji Kimata, in Hyaluronan in Cancer Biology, Hyaluronan synthase (HAS) expression provides powerful tools for understanding the in vivo function of hyaluronan (HA), particularly in connection with cancer cell behavior.

The central aim of the present review is to highlight the role of HA in cancer progression with respect to abnormal HA biosynthesis.

Summary The prelims comprise: Introduction Site of Biosynthesis Biosynthetic Precursors Hyaluronan Synthases Mechanism of Synthesis Regulation of HA Synthesis Concluding RemarksCited by: 9.

Hyaluronan Biosynthesis. The three related human HAS genes, i.e. HAS1, HAS2. and HAS3, are evolutionally conserved, yet the human. account for the intrinsic spatial regulation of the bio. Notably, the altered biosynthesis of hyaluronan, a constituent of the extracellular microenvironment, has been implicated in the progress and metastasis of carcinomas.

Aging and regulation of hyaluronan biosynthesis comparative studies on human skin fibroblasts and corneal keratocytes L Robert, I Fodil, N Isnard, F Dupuy, A Robert and G Renard Effects of KGF and TGF-B on Hyaluronan synthesis and distribution in extra- peri- and intracellular compartments of Regulation of Hyaluronan Biosynthesis book keratinocytes S Karvinen, M Tammi Regulation of Hyaluronan Biosynthesis book R.

growth factor regulation of hyaluronan biosynthesis Heldin, P Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. factor regulation of hyaluronan deposition in malignancies Altered hyaluronan biosynthesis in cancer progression Naoki Itano and Koji Kimata readers can now get an overview and understand the importance of hyaluronan in multiple cancers.

The book provides the first state-of-the-field summary and should be a highly useful and. Hyaluronan (HA) biosynthesis has been studied for over six decades, but our understanding of the biochemical details of how HA synthase (HAS) assembles HA is still incomplete. Class I family members include mammalian and streptococcal HASs, the focus of this review, which add new intracellular sugar-UDPs at the reducing end of growing.

Intended primarily for researchers working with bioactive substances such as hormones, neurotransmitters, growth factors, and connective tissue makers, this book discusses the principles of degradation in major groups of bioactive materials with respect to physiology, location, and regulation.

Peptidases; receptor-mediated endocytosis; organ extraction and clearance; and the degradation of. Abstract. The ubiquitous extracellular glycosaminoglycan hyaluronan (HA) is a polymer composed of repeated disaccharide units of alternating d-glucuronic acid and d-N-acetylglucosamine residues linked via alternating β-1,4 and β-1,3 glycosidic ng data continue to reveal functions attributable to HA in a variety of physiological and pathological contexts.

Hyaluronan (HA) is a linear polysaccharide with disaccharide repeats of D-glucuronic acid and N-acetyl-D-glucosamine. It is evolutionary conserved and abundantly expressed in the extracellular matrix (ECM), on the cell surface and even inside cells. Being a simple polysaccharide, HA exhibits an astonishing array of biological functions.

Abstract. Hyaluronan is a ubiquitous high-molecular weight polymer of repeated disaccharides of glucuronic acid and is a membrane-bound, viscous material extruded into the extracellular matrix after being synthesized in the cytoplasm by hyaluronan synthases complex and a regulated degradation by a group of enzymes called hyaluronidases.

Hyaluronan (HA) biosynthesis has been studied for over six decades, but our understanding of the biochemical details of how HA synthase (HAS) assembles HA is still incomplete.

Class I family members include mammalian and streptococcal HASs, the focus of this review, which add new intracellular sugar-UDPs at the reducing end of growing hyaluronyl-UDP chains. This review addresses the molecular mechanisms that regulate hyaluronan biosynthesis at both transcriptional and posttranslational levels, as well as the roles of hyaluronan deficiency or overproduction in various diseases, such as multiple myeloma, aggressive breast carcinomas, metabolic diseases and virus infection.

Suzuki M, Asplund T, Yamashita H, Heldin CH, Heldin P () Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C.

Biochem J (Pt 3)– PubMed PubMedCentral CrossRef Google Scholar. Xylan biosynthesis is not an exception and appears to be a surprisingly difficult process to study. Although several biochemical studies have investigated xylan biosynthesis in vitro using microsomal membranes from many grass species (Porchia and Scheller, ; Kuroyama and Tsumuraya, ; Porchia et al., ; Urahara et al., Hyaluronic acid (/ ˌ h aɪ.

ə l j ʊəˈr ɒ n ɪ k /; abbreviated HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large.

This book provides a comprehensive, up-to-date review of the structure, biology, and molecular interactions of proteoglycans, consolidating into a single source research using molecular, cellular, and animal systems.

Of particular note is an in-depth look at the role of heparan sulfate in modulating growth factors and morphogens. Sorsby’s fundus dystrophy (SFD) is an inherited blinding disorder caused by mutations in the tissue inhibitor of metalloproteinase-3 (TIMP3) gene.

The SFD pathology of macular degeneration with subretinal deposits and choroidal neovascularization (CNV) closely resembles that of the more common age-related macular degeneration (AMD). The objective of this study was to gain further insight. Association between cancer and "acid mucopolysaccharides": an old concept comes of age, finally --Hyaluronan-CD44 interactions and chemoresistance in cancer cells --Growth factor regulation of hyaluronan deposition in malignancies --Hyaluronan binding protein 1 (HABP1/p32/gClqR): a new perspective in tumor development --CD44 meets Merlin and.

Hyaluronan (HA), a glycosaminoglycan with important medical applications, is commercially produced from pathogenic microbial sources. The metabolism of HA-producing recombinant generally regarded as safe (GRAS) systems needs to be more strategically engineered to achieve yields higher than native producers.

Here, we use a genome-scale model (GEM) to account for the entire metabolic network of. Regulation of Collagen BiosynthesisCollagen biosynthesis is tightly regulated during normal development & homeostasis in a cell & tissue specific manner.

GENE TRANSCRIPTIONPOST TRANSLATIONAL MODIFICATIONThe changes at the gene transcription stage are reflected by dec in the mRNA levels and unstable With its acclaimed author team, cutting-edge content, emphasis on medical relevance, and coverage based on landmark experiments, Molecular Cell Biology has justly earned an impeccable reputation as an authoritative and exciting text.

The new Sixth Edition features two new coauthors, expanded coverage of immunology and development, and new media tools for students and instructors.3/5(7).

The book provides the first state-of-the-field summary and should be a highly useful and cited source for cancer biologists and hyaluronan researchers for many years."--Paul H. Weigel, Ph.D., Professor, Chairman George Lynn Cross Research Professor, Ed Miller Endowed Chair Biochemistry & Molecular Biology, The University of Oklahoma Health.

Hyaluronic acid is an essential part of connective, epithelialand neural tissues, and contributes to cell proliferation andmigration. It is used as a stimulating agent for collagen synthesisand is a common ingredient in skin-care products, a multi-billiondollar industry, as it is believed to be a key factor in fightingthe aging process.

Hyaluronan synthase 2 is an enzyme that in humans is encoded by the HAS2 gene. Hyaluronan or hyaluronic acid is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta and beta Enter search terms.

Keep search filters New search. Advanced search. regulation of biosynthesis and degradation of hyaluronan importance in tumorigenesis Heldin, P Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.

Using genome-wide transcriptional profiling and whole-mount expression analyses of zebrafish larvae, we have identified hyaluronan synthase 3 (has3) as an upregulated gene during caudal fin regeneration.

has3 expression is induced in the wound epithelium within hours after tail amputation, and its onset and maintenance requires fibroblast growth factor, phosphoinositide 3-kinase, and. Tammi R, Passi A, Rilla K, et al. Transcriptional and post-translational regulation of hyaluronan synthesis.

FEBS J ; (9): FEBS J ; (9): [41]. This introduction to the minireview series focuses on the emerging regulatory roles of hyaluronan in health and disease. The series describes the novel mechanism for biosynthesis of hyaluronan and fresh insights on the roles of its interaction with variants of the cell surface receptor CD Hyaluronan-CD44 axis orchestrates cancer stem cell functions.

Cell Signal. () Skandalis SS*, Karalis TT, Heldin P. Intracellular hyaluronan: Importance for cellular functions. Semin Cancer Biol.

() Heldin P, Lin CY, Kolliopoulos C, Chen YH, Skandalis SS. Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan.

Hyaluronan and its derivatives have developed very quickly in the last few years from a scientific novelty into an important new material for a diverse range of medical and biomaterial applications. Year: Publisher: You can write a book review and share your experiences. Other readers will always be interested in your opinion of the.

Hyaluronan Activates Cell Motility of v-Src-transformed Cells via Ras-Mitogen–activated Protein Kinase and Phosphoinositide 3-Kinase-Akt in a Tumor-specific Manner. Yasuyoshi Sohara, Naoki Ishiguro, Kazuya Machida, Hisashi Kurata, Aye Aye Thant, Takeshi Senga, Satoru Matsuda, Koji Kimata, Hisashi Iwata, and ; Michinari Hamaguchi.

Matrix Biology (established in as Collagen and Related Research) is a cutting-edge journal that is devoted to publishing the latest results in matrix biology welcome articles that reside at the nexus of understanding the cellular and molecular pathophysiology of the extracellular matrix.

FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short. Chen S, Evans HG, Evans DR. PLoS One. ; 7(3):e Epub Mar. 9, Synthesis of small peptides to probe oligomeric enzyme structure in pyrimidine biosynthesis.

Analysis of Human Hyaluronan Synthase Gene Transcriptional Regulation and Downstream Hyaluronan Cell Surface Receptor Mobility in Myofibroblast Differentiation.

Pages. Introduction. The extracellular matrix (ECM) has central roles in tissue integrity and remodeling. While collagens, laminins, and proteoglycans are the most abundant structural components of the ECM in most tissues, tissue‐specific molecular complexity during repair is determined by ECM glycoproteins and the capacity to secrete specific matricellular proteins.

Toole BP. Hyaluronan and its binding proteins, the hyaladherins. Curr Opin Cell Biol ; Knudson CB, Knudson W. Hyaluronan-binding proteins in development, tissue homeostasis, and disease. FASEB J ; Day AJ. The structure and regulation of hyaluronan-binding proteins.

Biochem Soc Trans. Objective: To examine the capacity of recombinant osteogenic protein-1 (OP-1) to inhibit the cartilage extracellular matrix damage that follows treatment with hyaluronan hexasaccharides (HA6).Design: The effects of OP-1 were examined on isolated human chondrocytes grown in alginate beads as well as articular cartilage slices treated with hyaluronan hexasaccharides.In this study, we investigated the effect of adiponectin on hyaluronan synthesis and its regulatory mechanisms in human dermal fibroblasts.

Adiponectin promoted hyaluronan synthesis along with an increase in the mRNA levels of hyaluronan synthase 2 (HAS2), which plays a primary role in hyaluronan synthesis.Careful observations by microbiologists and clinicians in the s and s pointed to a link between the hyaluronic acid capsule and group A streptococci (GAS) disease pathogenesis.

More recent studies have defined the genetic locus that directs hyaluronic acid biosynthesis and have characterized the molecular mechanisms through which the capsule enhances GAS virulence.